CLL Innovation Challenge

Advancing Tomorrow’s Care

We’re looking for innovative Israeli startups accelerating CLL care through advanced treatment management tools, improved patient navigation and enhanced quality of life – enabling more personalized, efficient, and comfortable care.

The Challenge

AbbVie Israel has partnered with Startup Nation Central to find innovative digital health solutions that improve the journey of Chronic Lymphocytic Leukemia (CLL) patients and healthcare providers.

By enhancing both quality of care and quality of life, we aim to transform CLL treatment initiation and patient care, making the process more straightforward, comfortable, and seamless for both patients and physicians.

As part of Startup Nation Central’s mission to connect global needs with Israeli innovation and drive scalable impact in sectors that matter, this challenge will accelerate the adoption of solutions that ease healthcare’s operational burden.

Could your technology be the next game-changer? 
Apply now.

What Will You Gain?

Collaboration with AbbVie Israel

The winner will receive exposure to relevant stakeholder within AbbVie & Startup Nation Central network.

 

Pilot
Opportunity

AbbVie Israel will partner with the winner to launch a pilot with an investment of up to 200,000 NIS.
 

Expert
Mentorship

Receive comprehensive mentorship from leading experts in medical, marketing, and business development from aMoon Fund and the oncology department at AbbVie Israel.
 

What Are We Looking For?

CLL is a chronic cancer requiring ongoing management and monitoring. Patients and caregivers face significant challenges, including frequent hospital visits and symptoms like fatigue and pain, which impact quality of life.

Thanks to recent advancements, time-limited therapies can now reduce disease burden to a level that enables treatment-free periods. AbbVie is committed to elevating standards of care and bringing transformative therapies to patients living with difficult-to-treat cancers such as CLL, allowing patients and caregivers to maintain a normal life routine is an essential part of disease-treatment management.

We seek solutions that seamlessly integrate into existing healthcare ecosystems and demonstrate real-world implementation potential in two key areas:

  • Remote monitoring technologies, including solutions for remote blood testing (e.g., chemistry panels) and adverse event tracking.
  • Technologies or services that improve patient experience and accessibility while minimizing daily disruptions.
  • Novel approaches for managing CLL-related fatigue and pain.
  • Digital health tools, wearables, or therapeutics that support symptom relief and overall well-being.
  • Patient-centric innovations that empower individuals to lead active and fulfilling lives

AbbVie Israel welcomes any additional solutions that improve quality of care or quality of life for CLL patients and their caregivers.

TRL 5

Solutions should have a Technology Readiness Level (TRL) of 5 and above.

Focus Area

Preference will be given to solutions addressing the areas of focus.

Multi-Use

Good solutions will address at least one focus area, while great solutions will tackle multiple areas, including technologies.

EMR-Ready

Priority will be given to solutions that integrate with Electronic Medical Records (EMR) based on FHIR.

Timeline

April 23
Applications Open
May 27
Applications Close
June 12
Finalists Notified
June 23
Finalists Pitch for Advisory Committee
July 1
Final Event

Advisory Committee

Yael Gruenbaum

Dr. Yael Gruenbaum-Cohen

Partner

aMoon Fund

dr avi matan

Dr. Avi Matan

General Manager

AbbVie Israel

Tamar Tadmor

Prof. Tamar Tadmor

Clinical Associate Professor Head of Hematology unit Bnai-Zion Medical Center

Giora Sharf

CEO

Flute of Light and CML Patients Organizations

Tamoschus David

Dr. David Tamoschus

Commercial Director, Venclyxto CLL, Oncology, Europe

AbbVie

Yair Hershno

Prof. Yair Herishanu

Hematology Specialist, Director of the CLL Unit and the Hematology Clinic

Ichilov Medical Center

Liat Alon

Liat Alon

CEX Director

AbbVie Israel

Moran Barak 2

Dr. Moran Barak

Medical Director

AbbVie Israel

Iris Adler

Dr. Iris Adler

Head of BD & Global Partnerships

8400 Health Network

Nataly Hason 2

Nataly Hason

Oncology Commercial Director

AbbVie Israel

Aya barak

Aya Barak-Meiri

External Affairs Director

AbbVie Israel

More About CLL

Chronic Lymphocytic Leukemia (CLL) is a type of cancer where B lymphocytes multiply uncontrollably in the bone marrow, the body’s blood production center.
Most cases are detected incidentally during routine blood tests when the absolute lymphocyte count exceeds 5,000 for more than three months. CLL typically progresses slowly but can cause:

  • Enlarged lymph nodes (painless but may press on organs if large).
  • Enlarged spleen or liver, leading to abdominal discomfort and early satiety.
  • Anemia, causing fatigue, weakness, and dizziness, due to either reduced red blood cell production or autoimmune destruction.
  • Thrombocytopenia (low platelets), increasing bleeding risk, especially when taking anticoagulants or certain supplements.
  • Weakened immune system, increasing susceptibility to infections.
  • General symptoms, such as weight loss, night sweats, persistent fever, and fatigue.

Diagnosis involves:

  1. Lymphocyte markers test (Immunophenotyping) using FACS technology to confirm CLL.
  2. Key markers: CLL cells express CD5 and CD19, along with CD20, a major treatment target.
  3. Bone marrow biopsy is usually unnecessary but may be done in specific cases.
  4. Once diagnosed, further lab tests and imaging determine disease progression and impact.

FAQ

The CLL Innovation Challenge seeks technologies and advanced solutions to reduce the treatment burden and improve the quality of care, for both CLL patients and HCPs, and to enhance the quality of life of CLL patients and their caregivers. We will explore all relevant opportunities to collaborate with the winning company by supporting the implementation of its solution in relevant sick fund/s or hospital/s or patients support programs etc.

No. This challenge is not equity or investment contingent. 

Privately held companies formed and registered under the laws of Israel with a company ID (חפ), or technology transfer offices/entities of non-profit and/or governmental entities (such as universities, hospitals and sick funds) (“TTO/s”), which develop a project/solution as defined by the Challenge and who have applied for patent protection underlying the technology subject of such project/solution. 

We welcome solutions with a Technology Readiness Level (TRL) of 5 and above.

English will be the official language of the challenge.

The challenge will be both online and in person. This will be communicated in advance.

One person will be required to pitch the startup and solution to the Advisory Committee and address all the questions from the Advisory Committee members.

For the mentoring meetings, we recommend that at least two team members from your startup attend, one business-oriented and another more tech-oriented, to cover a range of topics during the 1-on-1 sessions.

  • Complimentary pitch training and camera workshop prior to the final event
  • 3.5 hour meeting with the Advisory Committee, AbbVie Israel & Start-Up Nation Central at Startup Nation Central HQ, 28 Lilienblum, Tel-Aviv . In person attendance is mandatory.
  • Pitch to a local & global audience as part of the hybrid final event that will take place at Startup Nation Central HQ, 28 Lilienblum, Tel-Aviv ( Israel Time). In person attendance is mandatory.

AbbVie Israel will support a pilot program to implement the solution with a total value of up to 200,000 NIS.

Startup Nation Central is a free-acting NGO providing global solution seekers frictionless access to Israel’s bold and impatient innovators to help tackle the world’s most pressing challenges.

AbbVie’s mission is to discover and deliver innovative medicines and solutions that address complex health issues and enhance people’s lives. Our commitment is measured by the impact we make – to patients, to our communities, and to the world.

More than $63B invested in R&D since AbbVie’s launch in 2013 including $7.8B in adjusted R&D spend in 2023, and our approximately 50,000 employees strive to make a remarkable impact that lasts. Today our products help more than 60 million people living in more than 175 countries, and we are making significant advancements with a robust pipeline of potential new medicines as we look to find the treatments of tomorrow across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

Care, and lead the aesthetics space through Allergan Aesthetics.

By registering for the Challenge, you agree—on behalf of yourself and/or your organization—that each event may be recorded, and that both the recorded content and your and/or your organization’s name, image, logo, and biographical or related information may be used in Startup Nation Central marketing materials and/or for any other lawful purpose. You hereby waive any rights in connection with such use, including, without limitation, rights of privacy, publicity, or compensation.